They inhibit Nrf2 translocation into the nucleus and enhance NFB activation promoting inflammation and oxidative damage (Laforge et al., 2020)
Early studies proposed necrosis as the predominant mode of cell death, based on hallmark features including karyorrhexis, karyolysis, plasma membrane rupture, and a robust inflammatory response
V Bindokas and The Integrated Light Microscopy Core at The University of Chicago for the assistance with confocal imaging and analysis
sCT when bound to AMYRs induce a CT-like receptor conformation 15 , while P32Y substitutions of CT analogues are also detrimental to affinity and potency at AMYRs 18,19
doi: 10.1016/S0090-4295(98)00094-6
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